Midbits

Coenzyme is :

a.

Always a protein

c.

Always an inorganic compound

b.

Often a metal

d.

Often a vitamin

ANS: D PTS: 1

2. Enzymes are named after their substrates by adding suffix :

a.

-in

b.

-ase

c.

-ose

d.

–sin

ANS: B PTS: 1

3. Enzyme exist in the cells as-

a.

Solid

c.

Colloid

b.

Crystals

d.

None of the above

ANS: C PTS: 1

4. An enzyme brings about :

a.

Reduction in activation energy

c.

Increase in activation energy

b.

Increase in reaction time

d.

All the above

ANS: A PTS: 1

5. Which of the following statement is “NOT’ correct

a.

All enzymes are thermolabile

c.

All enzymes are proteins

b.

All enzymes are biocatalysts

d.

All proteins are enzymes

ANS: D PTS: 1

6. A __________is a biocatalyst that increases the rate of the reaction without bei

ng changed.

a.

Aluminum oxide

c.

Enzyme

b.

Silicon dioxide

d.

Hydrogen peroxide

ANS: C PTS: 1

7. What is the nature of an enzyme?

a.

Vitamin

b.

Lipid

c.

Carbohydrate

d.

Protein

ANS: D PTS: 1

8. Name the coenzyme of riboflavin (B2)?

a.

NAD or NADP

c.

Coenzyme A

b.

FAD and FMN

d.

Thiamine pyrophosphate

ANS: B PTS: 1

9. Which of this vitamin is associated with the coenzyme Biolytic?

a.

Nicotinic acid

b.

Thiamine

c.

Biotin

d.

Pyridoxine

ANS: C PTS: 1

10. Name the enzyme secreted by pancreas?

a.

Pepsin

c.

Trypsin

b.

Chymotrypsin

d.

Alcohol dehydrogenase

ANS: C PTS: 1

11. What is the function of phosphorylase?

a.

Transfer inorganic phosphate

c.

Use H2O2 as the electron acceptor

b.

Transfer a carboxylate group

d.

Transfer amino group

ANS: A PTS: 1

12. Mark the CORRECT function of enzyme, Peptidase?

a.

Cleave phosphodiester bond

c.

Remove phosphate from a substrate

b.

Cleave amino bonds

d.

Removal of H2O

ANS: B PTS: 1

13. Which of the following reaction is catalyzed by Lyase?

a.

Breaking of bonds

c.

Intramolecular rearrangement of bonds

b.

Formation of bonds

d.

Transfer of group

ANS: A PTS: 1

14. Which of the following is an example of ligases enzyme?

a.

Mutases

b.

Epimerizes

c.

Racemases

d.

Carboxylases

ANS: D PTS: 1

15. Which of the following is not a catalytic strategy for an enzyme to perform spec

ific reaction?

a.

Covalent catalysis

c.

Michaelis constant

b.

Metal ion catalysis

d.

Acid-base catalysis

ANS: C PTS: 1

16. What is the SI unit of enzyme activity?

a.

Km

b.

Kat

c.

Kcat

d.

Vmax

ANS: B PTS: 1

17. Which of the following is not an example of irreversible enzyme inhibitor?

a.

Cyanide

c.

Diisopropyl phosphoflouridate (DIPF)

b.

Sarin

d.

Statin drugs

ANS: D PTS: 1

18. Line weaver-Burk plot is also known as______

a.

Double reciprocal plot

b.

Hanes-Woolf plot

                     c. Eadie-Hofstee plot

                     d. Steady-state equation

ANS: A PTS: 1

19. Name the enzyme which is found in tears, sweat, and an egg white?

a.

Ribozymes

b.

Lysozyme

c.

Zymogens

d.

Isozymes

ANS: B PTS: 1

20. Law of thermodynamics which states that energy can neither be created nor be des

troyed is___________

a.

The second law

c.

First law

b.

Third law

d.

Zero-order kinetics

ANS: C PTS: 1

21. Which of the following equation shows the relationship between free energy chang

e (?G) and the change in entropy (?S), under constant temperature and pressure?

a.

?G = T?H – ?S

b.

b ?G = T?H/?S

c.

?G = ?H/T?S

d.

?G = ?H – T?S

ANS: D PTS: 1

22. What is the value of ?G, when a system is in equilibrium?

a.

?G = 0

b.

?G = 1

c.

?G = -1

d.

?G = ?G0

ANS: A PTS: 1

23. Which of the following factor is not responsible for the actual change in free e

nergy (?G)?

a.

Temperature

c.

The initial concentration

b.

Pressure

d.

pH

ANS: D PTS: 1

24. Which of the following equation gives the relationship between ?G? and Keq?

a.

?G0 = -RT ln Keq

c.

?G = ?G0 (-RT Keq)

b.

?G0 = ln Keq

d.

?G = -RT ln Keq

ANS: A PTS: 1

25. What is the standard free energy change of ATP?

a.

Small and negative

c.

Large and negative

b.

Large and positive

d.

Small and positive

ANS: C PTS: 1

26. Which of the following act as a storage form of high energy phosphate?

a.

Glucose-6-phosphate

c.

Phosphagens

b.

Phosphoenolpyruvate

d.

Glycerol phosphate

ANS: C PTS: 1

27. What is the name of the molecule which donates its electrons?

a.

Reducing agent

c.

Standard reduction potential

b.

Oxidative agent

d.

Oxidant

ANS: A PTS: 1

28. Chemical compounds involved in the process of metabolism is known as ________

a.

Metabolites

b.

Radicals

c.

Catabolites

d.

Intermediates

ANS: A PTS: 1

29. Which of the following has a spiral metabolic pathway?

a.

Glycolysis

c.

Glyoxylate cycle

b.

Citric acid cycle

d.

Fatty acid biosynthesis

ANS: D PTS: 1

30. Name the type of the pathway which is involved in the synthesis of compounds?

a.

Anabolic pathways

c.

Amphibolic pathway

b.

Catabolic pathways

d.

Anapleurotic pathway

ANS: A PTS: 1

31. Which of the following cycle shows Amphibolic pathway?

a.

Glyoxylate

b.

Citric acid cycle

c.

Glycolysis

d.

Lipid metabolism

ANS: B PTS: 1

32. Regulation of metabolic pathway is done by following ways except one, mark the o

ne?

a.

Substrate concentration

c.

Availability of oxygen

b.

Allosteric regulation of enzymes

d.

Extracellular signals i.e. hormones

ANS: C PTS: 1

33. Which of the following is not an enzyme-catalyzed reaction in metabolism?

a.

Isomerization and elimination

c.

Maillard reaction

b.

Internal rearrangement

d.

Free radical reaction

ANS: C PTS: 1

34. Name the inhibition where end products of biosynthesis pathway inhibit the activ

ity of the first enzyme?

a.

Feedback inhibition

c.

Allosteric inhibition

b.

Feedback repression

d.

Competitive inhibition

ANS: A PTS: 1

35. In which of the following phenomenon the end product act as co-repressor and rep

ress the synthesis of metabolic enzymes?

a.

Allosteric regulation

c.

Feedback inhibition

b.

Feedback repression

d.

Regulation by phosphorylation

ANS: B PTS: 1

36. What is the solubility of lipids in water?

a.

Soluble

b.

Partially soluble

c.

Insoluble

d.

Partially insoluble

ANS: C PTS: 1

37. Find the INCORRECT statement about the biological functions of lipids.

a.

Storage form of metabolic fuel

c.

The structural component of membranes

b.

Have a protective function biomes

d.

Exhibit increased catalytic activity

ANS: D PTS: 1

38. Which of the following is an example of unsaturated fatty acids?

a.

Lauric or Dodecanoic

c.

Palmitic or hexadecanoic

b.

Linoleic or octadecatrienoic

d.

Myristic or tetradecanoic

ANS: B PTS: 1

39. Name the two essential fatty acids?

a.

Linoleate and linolenate

c.

Lauric and Myristic

b.

Oleic and Linoleic

d.

Arachidonic and oleic

ANS: A PTS: 1

40. The melting point of fatty acids depends upon chain length and _________

a.

The shape of the fatty acids

c.

Charge on the carbon

b.

The position of the double bond

d.

Degree of unsaturation

ANS: D PTS: 1

41. Which of the following form of lipids are also referred as neutral lipids?

a.

Triacylglycerol

b.

Steroid

c.

Phospholipids

d.

Wax

ANS: A PTS: 1

42. Name the reagent which is used in Saponification?

a.

Ammonia

b.

Acetic acid

c.

NaOH/KOH

d.

Butanone

ANS: C PTS: 1

43. Which of the following is not a component of a phospholipids?

a.

Phosphate

b.

Alcohol

c.

Glycerol

d.

Protein

ANS: D PTS: 1

44. Which of the following phospholipids is considered as a major constituent of ner

vous tissue?

a.

Glycerophospholipid

c.

Inositol

b.

Plasmalogen

d.

Sphingomyelin

ANS: D PTS: 1

45. Which of the following sterol is present in the cell membrane of fungi?

a.

Ergosterol

b.

Stigmasterol

c.

Sitosterol

d.

Campesterol

ANS: A PTS: 1

46. Identify the lowest density lipoprotein among the following?

a.

HDL

b.

LDL

c.

VLDL

d.

Chylomicrons

ANS: D PTS: 1

47. Carbohydrates are also known as___________

a.

carbon

b.

Carbonates

c.

Glycolipids

d.

Polysaccharides

ANS: A PTS: 1

48. Class of carbohydrate which cannot be hydrolyzed further, is known as?

a.

Disaccharides

b.

Polysaccharides

c.

Proteoglycan

d.

Monosaccharide

ANS: D PTS: 1

49. Which class of carbohydrates is considered as non-sugar?

a.

Monosaccharide’s

c.

Polysaccharides

b.

Disaccharides

d.

Oligosaccharides

ANS: C PTS: 1

50. A molecule of amylopectin which contains 1500 glucose residues and is branched a

fter every 30 residues. How many reducing ends are there?

a.

0

b.

1

c.

2

d.

5

ANS: B PTS: 1

51. What is the name of the drug which inhibits Na+/K+ pump across the cell membrane

?

a.

Taxol

b.

Vinblastine

c.

Quinone

d.

Ouabain

ANS: D PTS: 1

52. Which of the following amino sugar are present in the bacterial cell wall?

a.

N-acetylmuramic acid

c.

Aminoglycoside

b.

Sialic acid

d.

Azide

ANS: A PTS: 1

53. Which of the following glycosidic linkage found in maltose?

a.

Glucose (α-1 – 2β) Fructose

c.

Galactose (β1 – 4) Glucose

b.

Glucose (α1 – 4) Glucose

d.

Glucose (β1 – 4) Glucose

ANS: B PTS: 1

54. Which of the following is also known as invert sugar?

a.

Sucrose

b.

Fructose

c.

Dextrose

d.

Glucose

ANS: A PTS: 1

55. Name the major storage form of carbohydrates in animals?

a.

Cellulose

b.

Chitin

c.

Glycogen

d.

Starch

ANS: C PTS: 1

56. Molecules which play the key role in the transfer of genetic information during 

protein synthesis are ___________

a.

DNA

b.

RNA

c.

Nucleic acid

d.

Lipids

ANS: B PTS: 1

57. Which form of structure has been adopted by RNA?

a.

A-form

b.

B-form

c.

Z-form

d.

D-form

ANS: A PTS: 1

58. Which of the following RNA molecule convert information stored in the nucleic ac

id to protein?

a.

tRNA

b.

mRNA

c.

rRNA

d.

snRNA

ANS: B PTS: 1

59. Which of the following RNA molecule convert information stored in the nucleic ac

id to protein?

a.

mRNA

b.

snRNA

c.

rRNA

d.

tRNA

ANS: D PTS: 1

60. Name the secondary structure of tRNA?

a.

Cloverleaf

b.

L-shaped

c.

Duplex

d.

Helix

ANS: A PTS: 1

61. Name the RNA molecule which takes part in the formation of the ribosome?

a.

mRNA

b.

tRNA

c.

rRNA

d.

gRNA

ANS: C PTS: 1

62. Which of the following rRNA molecules have peptidyl transferase activity in prok

aryotes?

a.

23S rRNA

b.

28S rRNA

c.

5S rRNA

d.

18S rRNA

ANS: A PTS: 1

63. Which of the following statement is Incorrect about SnRNA?

a.

It is small nuclear RNA

c.

It is also called snurps

b.

It helps in RNA splicing

d.

It functions in RNA editing

ANS: D PTS: 1

64. What is the role of snRNA in eukaryotes?

a.

Chemical modification

c.

Act as adaptor RNA

b.

RNA splicing

d.

Forms component of the ribosome

ANS: A PTS: 1

65. Name the class of RNA which takes part in RNA Editing?

a.

snRNA

b.

tRNA

c.

gRNA

d.

SiRNA

ANS: C PTS: 1

66. Who described the structure of DNA double helix?

a.

Peter Mitchell

c.

Ernest Uribe

b.

Andre Jagendorf

d.

Watson and Crick

ANS: D PTS: 1

67. Which form of DNA is described by Watson - Crick Model?

a.

B-DNA

c.

A-DNA

b.

Z-DNA

d.

Quadraplex DNA

ANS: A PTS: 1

68. How many base pairs are there in every helical turn of Watson-Crick double helix

 model?

a.

32.3

b.

11.6

c.

20

d.

10.4

ANS: D PTS: 1

69. Which one of the following statement is INCORRECT for Z-DNA?

a.

Left-handed DNA

c.

Only one deep, narrow groove

b.

Mostly in purine-pyrimidine sequences

d.

Anti glycosidic bond conformation

ANS: D PTS: 1

70. The third strand of triple helix is paired in which scheme?

a.

Hoogsteen base pair scheme

c.

Intramolecular base pair scheme

b.

Intermolecular base pair scheme

d.

G-quartet scheme

ANS: A PTS: 1

71. Name the nitrogenous base which is found in abundance in G-quadruplex?

a.

Adenine

b.

Guanine

c.

Cytosine

d.

Thymine

ANS: B PTS: 1

72. The stability and formation of G-quadruplex depends on __________

a.

Monovalent cation

c.

Bivalent cation

b.

Divalent cation

d.

Pentavalent ion

ANS: A PTS: 1

73. Which of this factor is not responsible for thermal Denaturation of DNA?

a.

PH

b.

Temperature

c.

Ionic strength

d.

Humidity

ANS: D PTS: 1

74. What is the term given to the super coiling of circular DNA?

a.

Twist number

b.

Linking number

c.

Writhe number

d.

Cross-linking

ANS: B PTS: 1

75. Which of them is used to introduce negative super coiling in DNA?

a.

Type 1 topoisomerase

c.

Gyrase/ type 2 topoisomerase

b.

Ethidium bromide

d.

SYBR gold

ANS: C PTS: 1

76. The monomeric unit of nucleic acid are called ___________

a.

Nucleotides

b.

Nucleosides

c.

Pyrimidines

d.

Purines

ANS: A PTS: 1

77. Who discovered nucleic acid?

a.

Watson and Crick

c.

Friedrich Miescher

b.

Griffith

d.

Walter Gilbert

ANS: C PTS: 1

78. Name the pyrimidine base which is found in RNA but not in DNA?

a.

Thymine

b.

Uracil

c.

Adenine

d.

Guanine

ANS: B PTS: 1

79. Name those purine bases which are commonly found in DNA and RNA?

a.

Adenine and guanine

c.

Adenine and thymine

b.

Cytosine and thymine

d.

Cytosine and guanine

ANS: A PTS: 1

80. What is the energy currency of the living cell?

a.

GTP

b.

NADH

c.

FADH

d.

ATP

ANS: D PTS: 1

81. The primary structure of DNA and RNA proceeds in which direction?

a.

3’ —–> 5?’

b.

5’ —–> 3’

c.

4’ —–> 6’

d.

3’ —–> 6’

ANS: B PTS: 1

82. Which bond is used to stabilize the double helix of DNA?

a.

Hydrophobic bond

c.

Covalent bond

b.

Hydrogen bond

d.

Ionic bond

ANS: B PTS: 1

83. A purified DNA sample of leaf contains 20.0 mole of guanine. Calculate the appro

ximate percentage of purine residues?

a.

30%

b.

40%

c.

60%

d.

20%

ANS: A PTS: 1

84. Protein folding is a process in which a polypeptide folds in to ___________

a.

2-D structure

b.

Globular form

c.

3-D structure

d.

Linear form

ANS: C PTS: 1

85. Which of them contains all the information required to fold the polypeptide chai

n in its 3-D structure?

a.

DNA sequences

c.

Histone protein

b.

RNA

d.

Amino acid sequences

ANS: D PTS: 1

86. Which of the following name is given to molecular chaperones?

a.

Allosteric protein

c.

Denaturation protein

b.

Heat shock protein

d.

Ribonuclease

ANS: B PTS: 1

87. Which of these heat shock proteins prevent protein misfolding and maintain polyp

eptide chain in the unfolded state?

a.

Hsp60

b.

Hsp28

c.

Hsp70

d.

Hsp32

ANS: C PTS: 1

88. Among all the heat shock proteins which one is known as chaperonins?

a.

Hsp70

b.

Hsp32

c.

Hsp60

d.

Hsp30

ANS: C PTS: 1

89. Which one of the following reagent is also known a Sanger’s reagent?

a.

1-fluoro-2,4-dinitrobenzene (FDNB)

c.

Cyanogen bromide

b.

Phenylisothiocyanate

d.

β-mercaptoethanol

ANS: A PTS: 1

90. Proteolytic enzyme Trypsin cleaves protein at which of these specific sites?

a.

Carboxyl side of Alanine, Glycine

c.

Carboxyl side of aromatic amino acid

b.

Carboxyl side of Lysine or Arginine

d.

The aromatic amino acid

ANS: B PTS: 1

91. In a living organism, strong interactions between molecules are formed by a cert

ain type of bond. Name that?

a.

Hydrogen bonding

c.

Electrostatic interactions

b.

Covalent bond

d.

Vander Waals forces

ANS: B PTS: 1

92. What is the fundamental unit of collagen?

a.

Tropocollagen

b.

Hydroxyproline

c.

Hydroxylysine

d.

Glycine

ANS: A PTS: 1

93. Name the protein which is responsible for extensibility and elasticity of connec

tive tissues.

a.

Collagen

b.

Elastin

c.

Actin

d.

Keratin

ANS: B PTS: 1

94. What is the name of protein which is found in nail, hair, and horns?

a.

Myoglobin

b.

Hemoglobin

c.

Keratin

d.

Collagen

ANS: C PTS: 1

95. The general structure of all amino acids are same except for ___________

a.

Lysine

b.

Glycine

c.

Proline

d.

Alanine

ANS: C PTS: 1

96. Which of these amino acids are not optically active?

a.

Cysteine

b.

Lysine

c.

Arginine

d.

Glycine

ANS: D PTS: 1

97. Which of these are used to measure optical activity?

a.

Polarimeter

b.

Planometer

c.

Psychrometer

d.

Photometer

ANS: A PTS: 1

98. Name the amino acid, which exists in two non-super imposable mirror images of ea

ch other.

a.

Epimer

b.

Anomer

c.

Enantiomer

d.

Chiral carbon

ANS: C PTS: 1

99. Which of these is rare amino acid in a protein?

a.

Leucine and serin

c.

Tryptophan and methionine

b.

Lysine and glutamic acid

d.

Leucine and lysine

ANS: C PTS: 1

100. In which amino acid Imidazole group, an aromatic ring found?

a.

Lysine

b.

Arginine

c.

Histidine

d.

Glutamate

ANS: C PTS: 1

101. What is the maximum wavelength that Tryptophan and tyrosine absorb?

a.

280nm

b.

260nm

c.

257nm

d.

230nm

ANS: A PTS: 1

102. How is the secondary structure of a protein stabilized?

a.

Vander wall forces

c.

Covalent bond

b.

Hydrogen bonding

d.

Hydrophobic bond

ANS: B PTS: 1

103. How many amino acid residues are there in per turn of α-helix?

a.

3.6

b.

4.6

c.

3.0

d.

2.5

ANS: A PTS: 1

104. Which biomolecule is distributed more widely in a cell?

a.

Chloroplast

b.

RNA

c.

DNA

d.

Spaherosome

ANS: B PTS: 1

105. Which is a reducing sugar?

a.

Galactose

c.

Sucrose

b.

Gluconic acid

d.

β-methyl galactosidase

ANS: A PTS: 1

106. Most abundant RNA in the cell

a.

rRNA

b.

mRNA

c.

tRNA

d.

tRNA  threonine

ANS: A PTS: 1

107. Name the simplest amino acid

a.

Alanine

b.

Tyrosine

c.

Asparagine

d.

Glycine

ANS: D PTS: 1

108. Mineral associated with cytochrome is

a.

Mg

b.

Cu and Ag

c.

Fe

d.

Cu

ANS: C PTS: 1

109. The most common secondary structure of proteins is

a.

β-pleated sheet

c.

β-pleated sheet non-parallel

b.

β-pleated sheet parallel

d.

α- helix

ANS: D PTS: 1

110. The term enzyme was coined by

a.

Urey Miller

b.

Pasteur

c.

Kuhne

d.

Buchner

ANS: C PTS: 1

111. β-oxidation occurs in

a.

Nucleus

b.

Cytoplasm

c.

Mitochondria

d.

Chloroplast

ANS: C PTS: 1

112. Khosland’s theory of enzyme action is known as

a.

Lock and key theory

c.

Induced fit theory

b.

Reduced fit theory

d.

Enzyme coenzyme theory

ANS: C PTS: 1

113. A high content of triglycerides are found in

a.

VLDL

b.

LDL

c.

HDL

d.

Chylomicrons

ANS: D PTS: 1

114. Which is the most abundant biomolecule on earth?

a.

Mineral salts

b.

Proteins

c.

Lipids

d.

Carbohydrates

ANS: D PTS: 1

115. In which of the following an anticodon occurs

a.

tRNA

b.

mRNA

c.

rRNA

d.

DNA

ANS: A PTS: 1

116. The fastest enzyme is

a.

DNA gyrase

c.

DNA polymerase

b.

Pepsin

d.

Carbonic anhydrase

ANS: D PTS: 1

117. Which of the following is phospholipids?

a.

Sterol

b.

Cholesterol

c.

Lecithin

d.

Steroid

ANS: C PTS: 1

118. The function of β subunit of polymerase is

a.

Template binding

b.

Catalytic binding

c.

Promoter binding

d.

Cation binding

ANS: B PTS: 1

119. Which of the σ factors is heat stable?

a.

σ 54

b.

σ 70

c.

σ 28

d.

σ 32

ANS: D PTS: 1

120. The mRNA codon of valine is

a.

GUC

b.

UGG

c.

CCA

d.

TTG

ANS: A PTS: 1

121. True replication of DNA is due to

a.

Phosphate backbone

c.

Complementary base pairing rule

b.

Hydrogen bonding

d.

None

ANS: C PTS: 1

122. Mode of DNA replication is

a.

Conservative and bidirectional

c.

Semi conservative and bidirectional

b.

Semi conservative and unidirectional

d.

Conservative and unidirectional

ANS: C PTS: 1

123. Which enzyme is used to join nicks in the DNA strand?

a.

Primase

c.

DNA ligase

b.

DNA polymerase

d.

Endonuclease

ANS: C PTS: 1

124. Which enzyme is used in the unwinding of DNA?

a.

Ligase

b.

Topoisomerase

c.

Helicase

d.

Exonuclease

ANS: C PTS: 1

125. Which of the following processes does not occur in prokaryotes?

a.

Transcription

b.

Splicing

c.

Translation

d.

Replication

ANS: B PTS: 1

126. cDNA is synthesized from RNA by the enzyme

a.

DNA polymerase

c.

DNA convertase

b.

DNA synthetase

d.

Reverse transcriptase

ANS: D PTS: 1

127. DNA synthesis can be measured by estimating the incorporation of radiolabelled

a.

Thymine

b.

Guanine

c.

Cytosine

d.

Adenine

ANS: A PTS: 1

128. How many RNA polymerases are present in a bacterial system?

a.

4

b.

2

c.

1

d.

3

ANS: C PTS: 1

129. Short strands of ——- primer are used in DNA replication.

a.

DNA

b.

RNA

c.

Hiastone

d.

Protein

ANS: B PTS: 1

130. During the formation of a peptide linkage, a(n) is formed.

a.

molecule of water

c.

hydrophobic bond

b.

disulfide bridge

d.

hydrophilic bond

ANS: A PTS: 1

131. Which of the following is responsible for making every amino acid unique?

a.

Amino group

b.

Hydrogen

c.

Carboxyl group

d.

"R" group

ANS: D PTS: 1

132. Enzymes are

a.

DNA

b.

blipids.

c.

carbohydrates

d.

proteins

ANS: D PTS: 1

133. A pentose sugar present in the heart muscle is---

a.

Xylose

b.

Xylulose

c.

Lyxose

d.

Aldose

ANS: C PTS: 1

134. α-D Glucose and β- D glucose are-

a.

Epimers

c.

Keto- Aldose Isomers

b.

Anomers

d.

Optical isomers

ANS: B PTS: 1

135. Glucose can have ————- isomers due to the presence of 4 asymmetric carbon atoms-

a.

4

b.

8

c.

12

d.

16

ANS: D PTS: 1

136. Galactose and Glucose are-

a.

Epimers

c.

Isomers

b.

Anomers

d.

Ketose- Aldose isomers

ANS: A PTS: 1

137. Which of the following monosaccharides is not an Aldose?

a.

Ribose

b.

Glucose

c.

Fructose

d.

Glyceraldehyde

ANS: C PTS: 1

138. The compounds having same structural formula but differing in configuration arou

nd one carbon atom are called-

a.

Optical isomers

b.

Anomers

c.

Stereo isomers

d.

Epimers

ANS: D PTS: 1

139. A Polysaccharide formed by β1?4 Glycosidic linkages is-

a.

Starch

b.

Glycogen

c.

Dextrin

d.

Cellulose

ANS: D PTS: 1

140. Invert sugar is-

a.

Starch

c.

Dextrin

b.

Glycogen

d.

Hydrolytic product of Sucrose

ANS: D PTS: 1

141. The polysaccharide found in the exoskeleton of insects is-

a.

Hyaluronic acid

b.

Chitin

c.

Cellulose

d.

Chondrosamine

ANS: B PTS: 1

142. The typical cyclical structure of Glucose is α and β D-

a.

Glucopyranose

b.

Glucofuranose

c.

Glucoside

d.

Glucosamine

ANS: A PTS: 1

143. Which of the following monosaccharides is not a carboxylic acid?

a.

Glucopyranose

b.

Glucose

c.

Glucoside

d.

Muramic acid

ANS: B PTS: 1

144. Which of following is an anomeric pair?

a.

D-glucose and L-glucose

c.

α-D-glucose and β-D-glucose

b.

D-glucose and D-fructose

d.

α-D-glucose and β-L-glucose

ANS: C PTS: 1

145. Which of these bacterial components is least likely to contain useful antigens?

a.

Cell wall

b.

Flagella

c.

Ribosomes

d.

Capsule

ANS: C PTS: 1

146. Which of the following contains structures composed of N-acetylmuramic acid and 

N- acetylglucosamine?

a.

Mycoplasmas

b.

Amoeba

c.

E.coli

d.

Spheroplast

ANS: C PTS: 1

147. The association of endotoxin in gram-negative bacteria is due to the presence of

a.

Steroids

b.

Peptidoglycan

 c. Lip polysaccharides

 d.         Polypeptide

ANS: A PTS: 1

148. The prokaryotic cell membrane

a.

Contains metabolic enzymes

c.

Regulates the entry and exit of materials

b.

Is selectively permeable

d.

Contains proteins and phospholipids

ANS: D PTS: 1

149. Which of the following is not a recognized cause of diarrhoea?

a.

Vibrio cholerae

c.

Clostridium perfringens

b.

Escherichia coli

d.

Enterococcus faecalis

ANS: D PTS: 1

150. Which of the following is a gram-positive eubacterium?

a.

Actinomyces

c.

Rhizobium

b.

Clostridium

d.

Clostridium, Actinomyces

ANS: D PTS: 1

151. Which of the following microorganisms is not responsible for urinary tract infec

tion?

a.

Proteus mirabilis

c.

Klebsiella pneumonia

b.

Escherichia coli

d.

Bacteroides fragilis

ANS: D PTS: 1

152. Which of the following is diagnosed by serologic means?

a.

Actinomycosis

c.

Pulmonary tuberculosis

b.

Q-f

d.

Gonorrhea

ANS: B PTS: 1

153. The bacterial genus where sterols are present in the cell membrane is

a.

Vibrio

b.

Mycoplasma

c.

Escherichia

d.

Chlamydia

ANS: B PTS: 1

154. The bacterium that infects other gram-negative bacteria is

a.

Proteus mirabilis

c.

Bdellovibrio

b.

Haemophilus influenza

d.

Pseudomonas putida

ANS: C PTS: 1

155. Which phage is used for phage display technique?

a.

T7

b.

M13

c.

?-phage

d.

?6

ANS: B PTS: 1

156. Which of the following is an example of Homology and similarity tool?

a.

BLAST

b.

RasMol

c.

EMBOSS

d.

PROSPECT

ANS: A PTS: 1

157. In which year did the SWISSPROT protein sequence database begin?

a.

1988

b.

1985

c.

1986

d.

1987

ANS: D PTS: 1

158. Which of the following scientists created the first Bioinformatics database?

a.

Dayhoff

b.

Pears

c.

Richard Durbin

d.

Michael.J.Dunn

ANS: A PTS: 1

159. The human genome contains approximately__________.

a.

6 billion base pairs

c.

3 billion base pairs

b.

5 billion base pairs

d.

4 billion base pairs

ANS: C PTS: 1

160. Which of the following tools is used for the identification of motifs?

a.

BLAST

b.

COPIA

c.

PROSPECT

d.

Pattern hunter

ANS: B PTS: 1

161. The first molecular biology server expasy was in the year __________.

a.

1992

b.

1993

c.

1994

d.

1995

ANS: B PTS: 1

162. What is the deposition of cDNA into the inert structure called?

a.

DNA probes

c.

DNA microarrays

b.

DNA polymerase

d.

DNA fingerprinting

ANS: C PTS: 1

163. The identification of drugs through the genomic study is called__________.

a.

Genomics

c.

Pharmacogenetics

b.

Pharmacogenomics

d.

Cheminformatics

ANS: B PTS: 1

164. Which of the following compounds has desirable properties to become a drug?

a.

Fit drug

b.

Lead

c.

Fit compound

d.

All of the above

ANS: B PTS: 1

165. Proteomics refers to the study of __________.

a.

Set of proteins in a specific region of the cell

b.

Biomolecules

c.

Set of proteins

d.

Proteins in the cell

ANS: D PTS: 1

166. The process of finding the relative location of genes on a chromosome is called 

__________.

a.

Gene tracking

c.

Genome mapping

b.

Genome walking

d.

Chromosome walking

ANS: C PTS: 1

167. The term Bioinformatics was coined by __________.

a.

J.D Watson

c.

Margaret Dayhoff

b.

Pauline Hogeweg

d.

Frederic Sanger

ANS: B PTS: 1

168. A Polysaccharide formed by β1?4 Glycosidic linkages is-

a.

Starch

b.

Glycogen

c.

Dextrin

d.

Cellulose

ANS: D PTS: 1

169. Which of the following is the genome of the virus?

a.

DNA

b.

RNA

c.

DNA or RNA

d.

DNA and RNA

ANS: C PTS: 1

170. Which of the following is the largest virus?

a.

Megavirus chilensis

c.

Herpes virus

b.

Arbo virus

d.

Mumps virus

ANS: A PTS: 1

171. Which of the following statements are true about the capsomeres?

a.

It is an individual unit of the capsid

c.

It is a unit of nucleic acid in viruses

b.

It is a viral protein for replication

d.

All of the above

ANS: A PTS: 1

172. Which of the following has a complex symmetry?

a.

T4 phage

b.

Adenovirus

c.

Influenza virus

d.

All of the above

ANS: A PTS: 1

173. Ribozymes are

a.

RNA acting as enzymes

c.

Antibodies acting as enzymes

b.

Ribose sugar acting as enzyme

d.

Protein acting as enzyme

ANS: A PTS: 1

174. Holoenzyme is made of

a.

Apo enzyme and Zymogene

c.

Co-enzyme and Prosthetic group

b.

Apo enzyme and coenzyme

d.

Prosthetic group and Co-factor

ANS: B PTS: 1

175. Which of the following organelle is called ‘Suicidal Bag’

a.

Mitochondria

c.

Lysosome

b.

Endoplasmic reticulum

d.

Ribosome

ANS: C PTS: 1

176. Bile salt surface tension

a.

Increases

c.

Both a and b

b.

Decreases

d.

None of the above

ANS: B PTS: 1

177. Most abundant blood cells in the human body are

a.

WBCs

b.

RBCs

c.

Platelets

d.

Plasma Cells

ANS: B PTS: 1

178. Number of iron atoms in one haemoglobin molecule are

a.

1

b.

3

c.

4

d.

8

ANS: C PTS: 1

179. Example of a Pro-enzyme

a.

Pepsinogen

b.

Trypsin

c.

Chymotrypsin

d.

Lysine

ANS: A PTS: 1

180. Abzymes are

a.

Proteins

b.

DNAs

c.

RNAs

d.

Antibodies

ANS: D PTS: 1

181. Which of the following is not a co-enzyme-

a.

NAD

b.

NADP

c.

FAD

d.

Mn++

ANS: D PTS: 1

182. Which enzymes do not require co-enzymes for their activity?

a.

The extracellular enzymes

c.

The mitochondrial enzymes

b.

The intracellular Enzymes

d.

The Proenzymes

ANS: A PTS: 1

183. What are ribozymes?

a.

RNA acting as enzymes

c.

Ribose sugar acting as enzymes

b.

Protein acting as enzymes

d.

Antibodies acting as enzymes

ANS: A PTS: 1

184. Activity of allosteric enzymes are influenced by

a.

Allosteric modulators

c.

Catalytic site

b.

Allosteric site

d.

None of the above

ANS: A PTS: 1

185. Feedback inhibition means-

a.

Initial product inhibition

c.

Enzymatic induction

b.

End Product inhibition

d.

None of the above

ANS: B PTS: 1

186. In competitive inhibition, inhibitors bears a close structural similarity with t

he

a.

Co-enzyme

b.

Co-factor

c.

Prosthetic group

d.

Substrate

ANS: D PTS: 1

187. Enzyme acts best at a particular temperature called

a.

Catalytic Temperature

c.

Optimum temperature

b.

At normal Body temperature

d.

None of the above

ANS: C PTS: 1

188. “Ping Pong” reaction is the other name for

a.

Single-substrate reaction

b.

Single-displacement bi-substrate reaction

c.

Double-displacement bi-substrate reaction

d.

Lysine

ANS: C PTS: 1

189. Uncatalyzed reaction shows activation energy

a.

Lower

b.

Higher

c.

Moderate

d.

Optimum

ANS: B PTS: 1

190. Lock and Key model is also known as

a.

Template model

c.

Khosland’s Model

b.

Induced fit model

d.

Enzyme-substrate interaction model

ANS: A PTS: 1

191. Which bond is not associated with Enzyme-substrate interaction -

a.

Hydrogen bonds

c.

Di-sulfide bonds

b.

Ionic bonds

d.

Van deer Waal’s force of attraction

ANS: C PTS: 1

192. Which of the following statement is incorrect

a.

Enzymes are protein in nature

c.

Enzymes are thermolabile

b.

Enzymes are colloidal in nature

d.

Enzymes are inorganic catalyst

ANS: D PTS: 1

193. Apo enzymes dissociates from co-enzymes due to

a.

Change in pH

c.

Change in substrate concentration

b.

Change in temperature

d.

Change in inhibitor concentration

ANS: A PTS: 1

194. Which of the following enzyme inhibitions shows decreased Km Value?

a.

Competitive inhibition

c.

Non-competitive inhibition

b.

Un-competitive inhibition

d.

Feedback inhibition

ANS: A PTS: 1

195. Reversible covalent modification involves

a.

Activation of Proenzymes

c.

Denaturation of Proenzymes

b.

Inhibition of Proenzymes

d.

None of the above

ANS: A PTS: 1

196. Amount of total blood volume in an individual is approximately-

a.

50 ml/Kg body weight

c.

90 ml/Kg body weight

b.

60 ml/Kg body weight

d.

80 ml/Kg body weight

ANS: D PTS: 1

197. Normal blood pH is

a.

7.3

b.

7.2

c.

7.4

d.

8.4

ANS: C PTS: 1

198. Ribosome’s are made up of

a.

RNA only

c.

RNA, DNA and Proteins

b.

RNA and Proteins

d.

nucleic acids, proteins and lipids

ANS: B PTS: 1

199. Apo enzyme is a

a.

Protein

b.

Carbohydrate

c.

Vitamin

d.

Amino acid

ANS: A PTS: 1

200. The enzyme which break up nucleic acid into nucleotides are called

a.

Nucleases

b.

Amylases

c.

Proteases

d.

Hydrolyses

ANS: A PTS: 10